SEVERAL new papers in the EDS space (list courtesy of incitefulmed!)
I get a weekly notification from Incitefulmed of new research papers in the EDS space! Here's the most recent articles:
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I get a weekly notification from Incitefulmed of new research papers in the EDS space! Here's the most recent articles:
Pharmacotherapeutic management of chronic pain in joint hypermobility and Ehlers-Danlos syndromes: a clinical perspective.
Expert opinion on pharmacotherapy, 2026
This review examined the evidence for using medications to treat chronic pain in people with joint hypermobility and Ehlers-Danlos syndromes. The authors found that current evidence is low-level and does not support the effectiveness of any specific drug for this type of pain, suggesting that a multimodal approach is more appropriate than medication alone.
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EXPRESS: Cerebral Microbleed Burden After Aortic and Cardiac Surgery Is Associated With Extracorporeal Circulation Exposure: Evidence From Young Patients With Heritable Connective Tissue Disorders.
Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026
In a study that looked back at records of 111 people with heritable connective tissue disorders, researchers found that all 58 patients who had surgery involving a heart-lung machine developed small brain bleeds. The number of these bleeds was higher in patients who had multiple surgeries or longer time on the heart-lung machine, though the study does not suggest these findings are specific to any one surgical technique.
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Contemporary Management of Subclavian and Axillary Artery Aneurysms in Connective Tissue Disease: Navigating Therapeutic Uncertainty in a Rare Vascular Disease Without Dedicated Guidelines.
Annals of vascular surgery, 2026
Researchers systematically reviewed 24 studies describing 43 artery aneurysms in 25 patients with connective tissue disorders, including 3 patients with vascular Ehlers-Danlos syndrome. The review found that open, endovascular, and hybrid surgical repairs achieved high technical success rates, with no reported deaths or limb loss during the study period. However, the authors note that follow-up was limited and that standardized management protocols for these fragile vessels are still needed.
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pubmed.ncbi.nlm.nih.gov/42899629/
pubmed.ncbi.nlm.nih.gov/42899414/
pubmed.ncbi.nlm.nih.gov/42880660/